Penske Racing has lost its initial appeal against the penalties NASCAR imposed on it and drivers Brad Keselowski and Joey Logano at Texas Motor Speedway last month.
The team had been forced to make rapid changes to its Fords just prior to the start at Texas after the cars failed pre-race technical inspections due to irregularities in the rear ends and suspension.
NASCAR subsequently levied heavy fines on the team, points deductions on both drivers and the squad itself, and multi-race suspensions for leading crew members on both cars.
The team's initial appeal was heard at NASCAR's technical center on Wednesday, but was rejected.
A NASCAR statement said: "Upon hearing the testimony and carefully reviewing the facts, it was a unanimous decision by the National Stock Car Racing Appeals Panel to uphold the original penalties assessed by NASCAR."
Penske has confirmed that it will now take its case to NASCAR's chief appellate officer, as allowed under series' rules.